How will Christian McCaffrey fare in his return to action? Which three rookies are about to go off? And in the wake of Ja'Marr Chase's transcendent performance, could ANOTHER receiver crack 200 yards?

Luke McCaffrey is one of Christian McCaffrey's three brothers ... played at Nebraska and Rice before Washington selected him ...

Technically, we still don't know if Christian McCaffrey will play this Sunday. 49ers head coach Kyle Shanahan said he expects ...

San Francisco 49ers running back Christian McCaffrey is set to make his season debut on Sunday against the Tampa Bay ...

The San Francisco 49ers have long viewed cornerback Deommodore Lenoir as one of their franchise cornerstones. They are now ...

San Francisco 49ers rookie offensive lineman Dominick Puni earned the highest Pro Football Focus weekly grade from the team's ...

The Week 10 main slate brought a lower median game total and fewer teams with elevated Vegas implied team totals. That ...

San Francisco 49ers running back Christian McCaffrey is a household name and the best running back in the NFL by a wide ...

The 49ers also signed running back Patrick Taylor Jr. to the practice squad and released running back KeShawn Vaughn. Taylor ...

Christian McCaffrey’s return to the lineup didn’t come with big numbers, but the star running back helped steady the San Francisco 49ers offense in Sunday’s 23-20 win over the Tampa Bay Buccaneers.

There are multiple games on the Week 11 NFL schedule that will have a huge ... Seattle at San Francisco: Christian McCaffrey showed signs of injury rust last week and yet still managed to post ...